Gastrointestinal stromal tumors (GISTs) are rare, representing only 0.1% to 3% of all gastrointestinal (GI) malignancies, but they account for 80% of GI mesenchymal neoplasms. Mazur and Clark coined the descriptive term in 1983 to define intra-abdominal noncarcinomatous neoplasms that lacked the ultrastructural features of smooth muscle cells and immunohistochemical characteristics of nerve cells.

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Gastrointestinal Stromal Tumors

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