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JANUARY 2, 2020

Study Shows Benefit for Appendectomy in Ulcerative Colitis Patients

Contradicting Past Research, Current Study Suggests Role as Possible ‘Last Resort’ Before Proctocolectomy

By Christina Frangou

Cleveland—For two decades, studies have shown an inverse relationship between appendectomy and ulcerative colitis. But the mechanism is unclear. Is it a placebo effect? Or does the appendix play a role, perhaps as a reservoir for harmful bacteria that contribute to ulcerative colitis?

A new study adds weight to the latter theory, showing that removing the appendix in severely ill patients with therapy-refractive ulcerative colitis (UC) offers a benefit in their quality