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OCTOBER 30, 2023

Trauma/Sepsis Model Reveals Sex Differences in Outcomes

Female Rats Showed Better Outcomes in Terms of Weight Loss, Renal Injury

By Chase Doyle

WEST LAKE VILLAGE, Calif.—A novel preclinical trauma/sepsis model has revealed sex-based differences in outcomes, with female rats having better results than their male counterparts. The study, presented at the 2023 annual meeting of the Surgical Infection Society, could lead to better understanding of the underlying pathophysiology and sexual dimorphism in post-injury sepsis, the study authors reported.

“Our model showed that polytrauma with post-injury sepsis resulted