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FEBRUARY 28, 2025

The Case for Population-Based Genetic Testing in Breast Cancer

By Monica J. Smith

ORLANDO, Fla.—When genetic testing guidelines were established in the 1990s, genetic tests were expensive and came with concerns about genetic discrimination, psychological harm and uncertainty about risk-reducing strategies and cancer risk outside the context of a strong family history.

“The [historical] view is that genetic tests have the potential to cause harm to patients, that we need to protect people from that risk by establishing guidelines that tell us who