Heparin Resistance as a Potential Indicator of Acquired and Hereditary Antithrombin Deficiency

Heparin Resistance as a Potential Indicator of Acquired and Hereditary Antithrombin Deficiency Faculty Stephen Bader, MD, FASA Anesthesiologist Heritage Valley Health System Beaver, Pennsylvania Christian Nicolosi, PharmD, BCPPS Pharmacy Department University of Maryland Medical Center Baltimore, Maryland Antithrombin (AT) is a natural anticoagulant that inhibits the activity of thrombin and several pro-coagulant enzymes.1 Low levels of functional AT impair normal inhibition of the coagulation